Injections of 0.01 mg/kg (up to 0.2 mg) can be administered and repeated atĦ0-second intervals where necessary (up to a maximum of 4 additional times) toĪ maximum total dose of 0.05 mg/kg or 1 mg, whichever is lower. If the desired level ofĬonsciousness is not obtained after waiting an additional 45 seconds, further Greater than 1 year of age, the recommended initial dose is 0.01 mg/kg (up toĠ.2 mg) administered intravenously over 15 seconds. Pediatric Patientsīenzodiazepines administered for conscious sedation in pediatric patients Sedation to the approximate endpoint desired and to minimize the possibility ofĪdverse effects (see Individualization Of Dosage). Single bolus injection) to allow the practitioner to control the reversal of
#Ativan antidote series
Injection be administered as the series of small injections described (not as a Than 3 mg should be given in any one hour. Than 1 mg (given as 0.2 mg/min) should be administered at any one time, and no more In the event of resedation, repeated doses may beĪdministered at 20-minute intervals as needed. To doses of 0.6 mg to 1 mg (see Individualization Of Dosage). Individualized based on the patient's response, with most patients responding Repeated at 60-second intervals where necessary (up to a maximum of 4Īdditional times) to a maximum total dose of 1 mg (10 mL). If the desired level of consciousness is not obtained after waiting anĪdditional 45 seconds, a second dose of 0.2 mg (2 mL) can be injected and Reversal Of Conscious Sedation Adult Patientsįor the reversal of the sedative effects ofīenzodiazepines administered for conscious sedation, the recommended initialĭose of flumazenil injection is 0.2 mg (2 mL) administered intravenously over 15 To minimize the likelihood of pain at the injection site,įlumazenil injection should be administered through a freely running As withĪll parenteral drug products, flumazenil injection should be inspected visuallyįor particulate matter and discoloration prior to administration, whenever For optimum sterility,įlumazenil injection should remain in the vial until just before use. If flumazenil injection is drawn into a syringe or mixed withĪny of these solutions, it should be discarded after 24 hours. It is compatible with 5% dextrose in water, lactated Ringer's and normal Pediatric Patients (aged 1 to 17)įlumazenil injection is indicated for the reversal ofĬonscious sedation induced with benzodiazepines (see PRECAUTIONS: Pediatricįlumazenil injection is recommended for intravenous use Procedures, and for the management of benzodiazepine overdose. Where sedation has been produced with benzodiazepines for diagnostic and therapeutic General anesthesia has been induced and/or maintained with benzodiazepines, Partial reversal of the sedative effects of benzodiazepines in cases where Each mL contains 0.1 mg of flumazenil compounded with 1.8 mg of methylparaben, 0.2 mg of propylparaben, 0.9% sodium chloride, 0.01% edetate disodium, and 0.01% acetic acid the pH is adjusted to approximately 4 with hydrochloric acid and/or, if necessary, sodium hydroxide.įlumazenil injection is indicated for the complete or Flumazenil injection is available as a sterile parenteral dosage form for intravenous administration. It is insoluble in water but slightly soluble in acidic aqueous solutions. Flumazenil has an imidazobenzodiazepine structure, a calculated molecular weight of 303.3, and the following structural formula:įlumazenil is a white to off-white crystalline compound with an octanol: buffer partition coefficient of 14 to 1 at pH 7.4.
Chemically, flumazenil is ethyl 8- fluoro-5,6-dihydro-5-methyl-6-oxo-4H-imidazo(1,4) benzodiazepine-3-carboxylate. DESCRIPTIONįlumazenil Injection, USP is a benzodiazepine receptor antagonist. You may report side effects to FDA at 1-80. For more information, ask your doctor or pharmacist.Ĭall your doctor for medical advice about side effects. These are not all the possible side effects of Romazicon. Tell the doctor if you have any side effect that bothers you or that does not go away. flushing (warmth, redness, or tingly feeling),.The most common side effects of Romazicon include: Get medical help right away, if you have any of the symptoms listed above. Romazicon may cause serious side effects including: What are the possible side effects of Romazicon? Romazicon belongs to a class of drugs called Benzodiazepine Toxicity Antidotes. Romazicon may be used alone or with other medications. Romazicon is a prescription medicine used as reversal of Conscious Sedation and General Anesthesia. Find Lowest Prices on What is Romazicon and how is it used?
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